Day 2
January 11, 2020
Day 2
Several motivations to investigate chromosome conformation:
Extract signals for more quantitative analyses:
The diagonal of Hi-C map contains useful information:
Distant-dependent contact decay follows a power-law
The slope of the curve gives compaction information
Can be used to compare polymer models
Adapted from Muller et al., 2018
Chromatin interaction domains are important for gene regulation:
Insulation: Contact depletion between domains
Insulation can be quantified with a numeric score.
Chen et al., 2018
Active and inactive chromatin is usually classified into A/B compartments
In Hi-C those compartments appear as a plaid-like pattern.
Dataset 4DNESYTUBW2E from Oksuz, Yang et al., bioRxiv 2020.